BIOCHEMICAL CHANGES IN Tilapia guineensis EXPOSED TO DIFFERENT CONCENTRATIONS OF PARAQUAT DICHLORIDE UNDER LABORATORY CONDITIONS

Abstract

Biochemical changes in Tilapia guineensis exposed to Paraquat Dichloride at various concentrations of 0.00 control,

0.05, 0.10, 0.15, 0.20 and 0.25 mg/L was carried out to determine the levels of alterations in fish exposed to this

chemical. A total of 180 T.guineensis were used for the study. Blood samples were collected from the exposed fish and

were analyzed with Randox test kits Results from the study indicated that the values of metabolites such as creatinine,

total bilirubin and total protein significantly reduced (P<0.05) in the exposed fish when compared to the control values,

while significant elevation (P < 0.05) was observed in urea. The antioxidants analysis showed that the values of SOD

and GSH reduced significantly (P<0.05), while CAT and LPO increased in both sizes when compared to the control.

Also, the enzymes analysis showed that all the enzymes under consideration were significantly (P<0.05) elevated when

compared to the control values. Moreover, the values of electrolytes such as Na + and K + ions significantly increased (P

< 0.05) in the exposed fish when compared to the control values, while significant reduction (P < 0.05) of Ca 2+ was

equally observed in the treated fish and no significant difference (P > 0.05) in the values of Cl - between th